Gallbladder disease can be caused by gallbladder inflammation, infection, stones, or obstruction. There is a pouch beneath the liver called the gallbladder. It gathers and holds the bile that the liver produces. In reaction to food, particularly lipids, the gallbladder releases bile into the upper small intestine, where it aids in the digestion of fat. Biliary colic—a term for the mildest and most prevalent kind of gallbladder pain—is an intermittent pain syndrome. The typical symptoms for a patient are a constant, strong gripping or gnawing pain in the upper right abdomen, close to the rib cage, that can also radiate to the upper back. The ache behind the breastbone is experienced by certain biliary colic patients. There could be vomiting or nausea.

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